Skeletal muscle relaxants are a broad class of pharmacological agents used for the treatment of muscle spasticity, although many of these agents cause a high degree of sedation. Evidence for the use of tizanidine Zanaflex and cyclobenzaprine Flexeril has shown benefit as short-term treatment agents, whereas evidence for the use of baclofen and dantrolene Dantrium in acute treatment is limited, and none exists for carisoprodol Soma or chlorzoxazone. Potential adverse effects from the long-term use of skeletal muscle relaxants include sedation, addictive potential, and hepatotoxicity. Evidence for acute treatment for each of these drugs is less than a month. The most evidence for the use of skeletal muscle relaxers in treating low back pain is with the use of cyclobenzaprine. Additionally, these studies demonstrate the efficacy of skeletal muscle relaxers for up to 14 days after symptom onset, and the evidence for long-term use is lacking.
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Rose Marchick has been publishing within the field of health and psychology since , writing and presenting research at conferences such as the Western Psychological Association. She has also written for numerous online publications. She specializes in psychological disorders, pharmacology, reproductive health, fetal alcohol syndrome and reactive attachment disorders. She holds a Ph.
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