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It is widely accepted that the highly error prone replication process of influenza A virus IAV , together with viral genome assortment, facilitates the efficient evolutionary capacity of IAV. Therefore, it has been logically assumed that the enzyme responsible for viral RNA replication process, influenza virus type A RNA polymerase IAV Pol , is a highly error-prone polymerase which provides the genomic mutations necessary for viral evolution and host adaptation. Here we established new biochemical assay conditions that enabled us to assess both polymerase activity with physiological NTP pools and enzyme fidelity of IAV Pol. With this robust enzyme activity, for the first time, we were able to compare the enzyme fidelity of IAV Pol complex with that of bacterial phage T7 RNA polymerase and the reverse transcriptases RT of human immunodeficiency virus HIV-1 and murine leukemia virus MuLV , which are known to be low and high fidelity enzymes, respectively.
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What's your reality? A VR primer

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What's your reality? A VR primer | Building Design + Construction

The Nissan Sentra is a car produced by Nissan since Originally subcompact in classification, for model year it was reclassified as a compact car. Until , Sentra was a rebadged export version of the Japanese Nissan Sunny , but since the model year, Sentra is a rebadged export version of the Nissan Sylphy B The Sentra nameplate is not used in Japan. Many other countries in South America sell their versions of the Sunny as the Sentra. In Mexico, the first three generations of the Sentra were known as the Nissan Tsuru Japanese for crane , and the B13 model was sold under that name until , alongside the updated models badged as Sentra. In North America, the Sentra currently serves as Nissan's compact car, despite being rated as a mid-size car by the EPA due to its interior volume since the model year.
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Histone H3. Germline and somatic mutations in H3. However, the role of H3.
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University of Michigan Press Bolero Ozon. Middle English Dictionary. The goal of the Middle English Dictionary is to include all meanings, grammatical forms, and spellings of all the words identified by its extensive reading program. When completed, it will represent what has been called the greatest achievement in medieval scholarship in America and the most important single project in English historical lexicography being carried out anywhere today. After sixty-five years it will have produced about 15, pages.
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